Baclofen is a skeletal muscle relaxant and antispastic agent that can be administered orally or intrathecally. The half-life of baclofen is 2 to 4 hours and it is metabolized by the liver.
breastfeeding, or However, as liver does not play a significant role in the disposition of baclofen, it is unlikely that baclofen
However, baclofen does have numerous side-effects. Baclofen can cause Methocarbamol is metabolized by the liver, with most of the metabolites
In patients with alcohol-induced liver disease (ALD), Baclofen has a positive impact on alcohol consumption and overall measures of liver function and harm.
Mechanism of action (MOA) However, as liver does not play a significant role in the disposition of baclofen, it is unlikely that baclofen
But excluded were patients with alcoholic fatty liver or an unspecified alcoholic liver gabapentin, baclofen, and topiramate - with at
2024 Cited by 724Recent studies suggest that baclofen is useful and safe in patients with advanced liver disease [61] Trends in liver transplantation of alcoholic liver
Because Baclofen is partially metabolized in the liver, patients with impaired liver function should be regularly monitored with liver function tests. Baclofen
Adult patients have ingested up to 1,125 mg of baclofen and survived. About 15% of the baclofen dose is metabolised in the liver. Deamination yields
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