Thioamide drugs

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Actual: The thioamide motif is deeply inserted into the ASH1L pocket, forming two hydrogen bonds with the carbonyl groups of Cys2195 and Phe2260, and one chalcogen bond with the carbonyl group of His2193. These favorable interactions underscore the vital role of the thioamide in drug design.
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Thioamide substitution to probe the hydroxyproline recognition of VHL ligands. Division of Biological Chemistry and Drug Discovery

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Thioamide antithyroid drugs are a class of medications used to treat hyperthyroidism (an overactive thyroid gland).

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As new biological functions are uncovered for natural thioamides, these can inform the use of thioamides in a designed fashion, leading to applications beyond the current directions of improving the stability and activity of peptide drugs. Of course, the study of thioamide-containing peptides and proteins in biophysical and medicinal chemistry

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by SK Hadjikakou 2024This presentation is a brief review on the results of our work on iodine interaction with thioamides, selenoamides and amides. The thioamides

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Drugs for hyperthyroidism Thioamides, such as carbimazole and propylthiouracil, inhibit thyroid peroxidase and interfere with the formation of thyroid

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Thiocyanuric acid is a tristhioamide. Thioamides or anti-thyroid drugs are also a class of drugs that are used to control thyrotoxicosis.

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Thioamides are also a class of drugs which are used to control thyrotoxicosis. Incorporation of thioamides into peptides are used as isosters

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a Examples and importance of thioamide moieties in bioactive compounds.b and c Current strategies and common limitations for thioamide synthesis.b An O S exchange approach requires the use of

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A well-known thioamide is thioacetamide, which is used as a source of the sulfide ion and is a building block in heterocyclic chemistry. Thiocyanuric acid is a tristhioamide. Thioamides or anti-thyroid drugs are also a class of drugs that are used to control thyrotoxicosis.

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