Are platinum drugs renally cleared

platinum and 5FU or the FLOT regimen are all options . Targeted renal replacement therapy needs. While the progression of CKD

by CE Humber 2024 Cited by 213While no one drug or regimen offers a clear benefit for women with advanced endometrial cancer, platinum drugs, anthracyclines and paclitaxel seem the most

kidneys and the degree of RI. For drugs cleared primarily by renal excretion (e.g, gabapentin and pregabalin), even a mild degree of renal

by C Massari 2024 Cited by 111They also reveal a strong negative correlation between free drug plasma availability and renal clearance of the plasmatic platinum and renal function. Thus

Newer platinum agents such as this medication is not renally cleared and does not require dose adjustments in patients with renal insufficiency. Bortezomib should be given after dialysis in

Patients with known severe hypersensitivity to platinum containing compounds Anticancer drug renal toxicity and elimination: dosing guidelines for altered.

by Y Soma 2024 Cited by 1Oxaliplatin is associated with less frequent renal dysfunction than other conventional platinum-based drugs such as cisplatin [3]. Despite that

For renally excreted drugs with a narrow therapeutic index, the total daily platinum. compounds of nephrotoxicity and possibly of ototoxicity.

The other one important aspect of platinum resistance is that oxaliplatin is the only platinum drug recommended for platinum resistance current .The aim is to choose the appropriate platinum drugs used for chemotherapy, which could help to reduce adverse drug reactions in important target organs and reduce the occurrence of platinum resistance