2.1. Chemicals and reagents. Sibutramine hydrochloride (SB) was purchased from Symed labs. N-des-methyl sibutramine hydrochloride (DSB), N-di-desmethyl sibutramine hydrochloride (DDSB), sibutramine d7 hydrochloride (SB d7), N-des-methyl sibutramine d7 hydrochloride (DSB d7), N-di-des methyl sibutramine d7 hydrochloride (DDSB d7) were obtained from Toronto Research Chemicals, Canada (Fig. 1).
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