(Unlike, for example, non-anion-gap metabolic acidosis – where most causes are not life threats). Review the medication list and discontinue
It is not always clear whether these conditions cause metabolic acidosis, or whether acidosis causes these conditions. Drug-induced acidosis. Some prescription medications can increase acidity
5. Metabolic Acidosis Due to Drugs and Toxins: Many drugs and toxins have been identified as direct or indirect causes of metabolic acidosis
hyperkalemia and metabolic acidosis, while carbonic anhydrase inhibitors such as acetazolamide can cause hypokalemia and metabolic acidosis.
Most symptoms are caused by the underlying disease or condition that is causing the metabolic acidosis. Metabolic acidosis itself most often causes rapid breathing. Acting confused or very tired may also occur. Severe metabolic acidosis can lead to shock or death. In some situations, metabolic acidosis can be a mild, ongoing (chronic) condition.
The drugs that can cause or contribute to metabolic acidosis during therapeutic use are described, the mechanisms by which this occurs, and how they may be identified in practice are described. Summary Drug causes of metabolic acidosis are numerous and their mechanisms are diverse. Broadly, they can cause metabolic acidosis with either a normal anion gap (e.g. drug-induced renal tubular
This drug can cause metabolic acidosis. The effect of topiramate-induced metabolic acidosis has not been studied in pregnancy; however, metabolic acidosis in pregnancy (due to other causes) can cause decreased fetal growth, decreased fetal oxygenation, and fetal death, and may affect the ability of the fetus to tolerate labor.
Metabolic acidosis is common in acutely unwell patients and indicates an underlying pathophysiological disturbance. Treatment should be primarily directed at the underlying condition, not the acidosis. Thus, a key element of managing metabolic acidosis is determining the underlying cause. In most cases, metabolic acidosis is caused by increased plasma concentrations of pathologic anions and
by K Glassman 2024 Cited by 1acidosis (RTA) that can cause metabolic acidosis: 1. Defects Drug Shortage Lists a. American Society of Health-System Pharmacists
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