Applies to: Tramadol Hydrochloride ER (tramadol) and melatonin Using traMADol together with melatonin may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination.
by F Alshehri 2024Male Wistar rats were classified into 4 groups 1) control 2) tramadol 3) tramadol melatonin (one dose), and 4) trama- dol melatonin (multiple doses).
Melatonin and N- Acetylcysteine as Remedies for Tramadol-Induced Hepatotoxicity in Albino Rats.
melatonin. tramadol and melatonin both increase sedation. Use Caution/Monitor. meperidine.
melatonin. tramadol and melatonin both increase sedation. Use Caution/Monitor. meperidine.
Melatonin and melatonin receptor agonists, on market The risk or severity of CNS depression can be increased when Melatonin is combined with Tramadol.
The rats were divided into four groups: control, tramadol, tramadol melatonin (single dose), and tramadol melatonin (repeated doses). Tramadol was administered intraperitoneally at 40 mg/kg, while melatonin was administered at 50 mg/kg for both the single dose and repeated-dose groups.
Melatonin and N- Acetylcysteine as Remedies for Tramadol-Induced Hepatotoxicity in Albino Rats.
Tramadol melatonin (Repeated doses) Tramadol (40 mg/kg, i.p)Melatonin (50 mg/kg, i.p), five doses during acquisition FIGURE 2 CPP score for the effect of melatonin and tramadol in CPP on all groups (control, tramadol, tramadol melatonin single dose, and tramadol melatonin repeated doses ). Frontiers in Pharmacology 03
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