How long does it take amitriptyline to leave your system

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Actual: How long does amitriptyline stay in your system? On average, it takes hours for half of an amitriptyline dose to leave your body. Typically, it takes about five half-lives for a drug to leave your system. So with all of this in mind, amitriptyline will stay in your system for about 2 to 6 days after your last dose.
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